CBSE 2025, Set 2

Question

Assertion (A): A patient of ADA-deficiency requires periodic or repeated infusion of genetically-engineered lymphocytes.
Reason (R): Lymphocytes are not immortal, but have life span.

Select the correct option: A). Both (A) and (R) are true, and (R) is the correct explanation of (A). B). Both (A) and (R) are true, but (R) is not the correct explanation of (A). C). (A) is true, but (R) is false. D). (A) is false, but (R) is true.

Edvaya · Accepted Answer

The correct answer is Both (A) and (R) are true, and (R) is the correct explanation of (A).. **SOLUTION** Both statements are scientifically accurate. In gene therapy for ADA (Adenosine deaminase) deficiency, lymphocytes from the patient are genetically engineered to carry a functional ADA gene and returned to the patient. However, because these mature white blood cells are **not immortal** and have a definite, finite life span, they eventually die off. This makes the treatment non-permanent, thereby requiring the patient to undergo **periodic infusions** of fresh genetically-engineered lymphocytes.

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